What is the largest Health Care ETF?

State Street® Health Care Select Sector SPDR® ETF (XLV) is the largest Health Care ETF tracked by Nukoud, with $43,502 million in assets.

Which Health Care ETF has the lowest expense ratio?

State Street® Health Care Select Sector SPDR® ETF (XLV) charges 0.08% a year, the lowest fee among 5 Health Care ETFs.

Are there Health Care ETFs listed in the GCC?

Not yet. None of the 5 Health Care ETFs tracked by Nukoud is listed on a GCC exchange; all are available through international brokers.

Are any Health Care ETFs Shariah-compliant?

None of the 5 Health Care ETFs currently tracked is marketed as Shariah-compliant.

How much do Health Care ETFs cost?

Expense ratios range from 0.08% to 0.75%, with a median of 0.50% a year.

Sector

Health Care ETFs

Nukoud tracks 5 Health Care ETFs across 1 listing market (5 on United States). Combined assets under management are $56,300 million. The median expense ratio is 0.50%. The largest fund is State Street® Health Care Select Sector SPDR® ETF (XLV) at $43,502 million. Use the table to compare fees, size and year-to-date performance, or open the screener to refine the list.

Data as of 2026-09-20 · Summary generated from fund data

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ETFs: 5
Combined AUM: $56.30B
Median fee: 0.500%
Avg YTD: +34.87%
Listed on: United States · 5
Shariah-compliant: None

All health care etfs

Sorted by assets. Click a column to re-sort; type to filter.

5 ETFs

Health Care ETFs: ticker, name, exposures, assets, expense ratio and returns
Ticker	Name	Exposures	AUM (USD)	Expense ratio	YTD	1Y	Listed
XLVUS	State Street® Health Care Select Sector SPDR® ETF	US	$43.50B	0.080%	+9.70%	+24.62%	US
IBBUS	iShares Biotechnology ETF	Biotechnology US	$10.45B	0.440%	+21.32%	+42.71%	US
ARKGUS	ARK Genomic Revolution ETF	Genomics Active	$2.21B	0.750%	+78.25%	+87.14%	US
GNOMUS	Global X Genomics & Biotechnology ETF	Biotechnology Genomics	$99.99M	0.500%	+46.22%	+77.46%	US
HELXUS	Franklin Genomic Advancements ETF	Genomics Active	$32.16M	0.500%	+18.86%	+39.89%	US

Largest by assets

1XLVUSState Street® Health Care Select Sector SPDR® ETF$43.50B
2IBBUSiShares Biotechnology ETF$10.45B
3ARKGUSARK Genomic Revolution ETF$2.21B
4GNOMUSGlobal X Genomics & Biotechnology ETF$99.99M
5HELXUSFranklin Genomic Advancements ETF$32.16M

Lowest expense ratio

1XLVUSState Street® Health Care Select Sector SPDR® ETF0.080%
2IBBUSiShares Biotechnology ETF0.440%
3GNOMUSGlobal X Genomics & Biotechnology ETF0.500%
4HELXUSFranklin Genomic Advancements ETF0.500%
5ARKGUSARK Genomic Revolution ETF0.750%

Terms that share funds with Health Care. Each number is how many health care etfs also carry that exposure.

Other sector lists

Frequently asked questions

What is the largest Health Care ETF?: State Street® Health Care Select Sector SPDR® ETF (XLV) is the largest Health Care ETF tracked by Nukoud, with $43,502 million in assets.
Which Health Care ETF has the lowest expense ratio?: State Street® Health Care Select Sector SPDR® ETF (XLV) charges 0.08% a year, the lowest fee among 5 Health Care ETFs.
Are there Health Care ETFs listed in the GCC?: Not yet. None of the 5 Health Care ETFs tracked by Nukoud is listed on a GCC exchange; all are available through international brokers.
Are any Health Care ETFs Shariah-compliant?: None of the 5 Health Care ETFs currently tracked is marketed as Shariah-compliant.
How much do Health Care ETFs cost?: Expense ratios range from 0.08% to 0.75%, with a median of 0.50% a year.